236 research outputs found
Nitrate subsurface transport and losses in response to its initial distributions in sloped soils: An experimental and modelling study
Transport and losses of nitrate from sloped soils are closely linked to nitrogen fertilizer management. Previous studies have always focused on different types of fertilizer applications and rarely analysed various initial nitrate distributions as a result of nitrogen fertilizer applications. Under certain conditions, both subsurface lateral saturated flow and vertical leaching dominate nitrate losses. Soil tank experiments and HYDRUS-2D modelling were used to better understand the subsurface nitrate transport and losses through lateral saturated flow and vertical leaching under various initial nitrate distributions. Low (L: 180 mg L−1), normal (N: 350 mg L−1), and high (H: 500 mg L−1) nitrate concentrations were used in five different distributions (NNNN, NLLN, LHHL, LNLN, and HNHN) along the slope of the tank. The first two treatments (NNNN and NLLN) were analysed both experimentally and numerically. Experiments were conducted under 12 rainfall events at intervals of 3 days. The HYDRUS-2D model was calibrated and validated against the experimental data and demonstrated good model performance. The other three treatments (LHHL, LNLN, and HNHN) were investigated using the calibrated model. Nitrate concentrations in purple sloped soils declined exponentially with time under intermittent rainfalls, predominantly in the upper soil layers. Non-uniform initial nitrate distributions contributed to larger differences between four locations along the slope in deeper soil layers. The non-uniform nitrate distribution either enhanced or reduced decreases in nitrate concentrations in areas with higher or lower initial nitrate concentrations, respectively. Higher nitrate concentrations at the slope foot and along the slope were reduced mainly by lateral flow and vertical leaching, respectively. Increasing nitrogen application rates increased subsurface nitrate losses. Mean subsurface lateral nitrate fluxes were twice as large as mean vertical leaching nitrate fluxes. However, due to longer leaching durations, total nitrate losses due to vertical leaching were comparable with those due to lateral flow, which indicated comparable environmental risks to surface waters and groundwater
Analysis of the Role of Tortuosity and Infiltration Constants in the Beerkan Method
It has recently been proposed to couple the Beerkan method with the Beerkan
Estimation of Soil Transfer parameters (BEST) algorithm to facilitate the estima-
tion of soil hydraulic parameters from an infiltration experiment. Although this
simplified field procedure is relatively rapid and inexpensive, it has been doubt -
ed if the Beerkan method can represent a valid and reliable alternative to other
conventional methods. This study explored the impact of the tortuosity param-
eter (p) and two infiltration constants included in the BEST algorithm
using a sensitivity analysis applied to three experimental soils. The analysis that
was validated using the numerical model HYDRUS 2D/3D indicates that the
tortuosity is relatively insignificant compared to parameters b and g that have a
large impact on the estimation procedure
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Assessing salinity leaching efficiency in three soils by the HYDRUS-1D and -2D simulations
Salinity leaching is necessary to sustain agricultural production in irrigated croplands. Improving salinity leaching efficiency not only conserves water but also reduces groundwater contamination. Current leaching requirement (LR) calculations are based on steady-state and one-dimensional (1D) approaches, and consequently, this LR concept may not be applicable to drip irrigation (approximately 2D), which is becoming more common due to its higher water use efficiency. The aims of this study were to assess the salinity leaching fraction (LF) in clay, loam, and sand soils under 1D (to mimic sprinkler irrigation) and 2D (to mimic drip irrigation) transient conditions with a numerical model (HYDRUS). Water applications used the actual irrigation scheme in an almond orchard located in central California without considering precipitation. Model simulations showed that soil salinity at the lower boundary (depth of 150 cm) reached steady-state in 10 years in HYDRUS-1D simulations. The leaching fractions calculated from the ratio of drainage-water depth to irrigation-water depth (LFw = Ddw/Diw) and irrigation-water salinity to drainage-water salinity (LFEC = ECiw/ECdw) from HYDRUS-1D were similar among different textured soils. However, they were much higher under drip irrigation (2D) than under sprinkler irrigation (1D) when the same amount of water was applied, and LFEC values were much greater than the LFw values under 2D simulations. Salt balance (SB) and leaching efficiency (LE) indicated that sprinkler irrigation (1D) is more effective for salinity leaching than drip irrigation (2D). To improve salinity leaching efficiency, further evaluation of LRs under drip irrigation is needed
Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage
Anthracyclines, such as doxorubicin (adriamycin), daunorubicin, or epirubicin, rank among the most effective agents in classical anticancer chemotherapy. However, cardiotoxicity remains the main limitation of their clinical use. Topoisomerase IIβ has recently been identified as a plausible target of anthracyclines in cardiomyocytes. We examined the putative topoisomerase IIβ selective agent XK469 as a potential cardioprotective and designed several new analogues. In our experiments, XK469 inhibited both topoisomerase isoforms (α and β) and did not induce topoisomerase II covalent complexes in isolated cardiomyocytes and HL-60, but induced proteasomal degradation of topoisomerase II in these cell types. The cardioprotective potential of XK469 was studied on rat neonatal cardiomyocytes, where dexrazoxane (ICRF-187), the only clinically approved cardioprotective, was effective. Initially, XK469 prevented daunorubicin-induced toxicity and p53 phosphorylation in cardiomyocytes. However, it only partially prevented the phosphorylation of H2AX and did not affect DNA damage measured by Comet Assay. It also did not compromise the daunorubicin antiproliferative effect in HL-60 leukemic cells. When administered to rabbits to evaluate its cardioprotective potential in vivo, XK469 failed to prevent the daunorubicin induced cardiac toxicity in either acute or chronic settings. In the following in vitro analysis, we found that prolonged and continuous exposure of rat neonatal cardiomyocytes to XK469 led to significant toxicity. In conclusion, this study provides important evidence on the effects of XK469 and its combination with daunorubicin in clinically relevant doses in cardiomyocytes. Despite its promising characteristics, long-term treatments and in vivo experiments have not confirmed its cardioprotective potential
Polarized x-ray absorption spectra of CuGeO3 at the Cu and Ge K edges
Polarized x-ray absorption near edge structure (XANES) spectra at both the Cu
and the Ge K-edges of CuGeO3 are measured and calculated relying on the
real-space multiple-scattering formalism within a one-electron approach. The
polarization components are resolved not only in the unit cell coordinate
system but also in a local frame attached to the nearest neighborhood of the
photoabsorbing Cu atom. In that way, features which resist a particular
theoretical description can be identified. We have found that it is the
out-of-CuO4-plane p_{z'} component which defies the one-electron calculation
based on the muffin-tin potential. For the Ge K-edge XANES, the agreement
between the theory and the experiment appears to be better for those
polarization components which probe more compact local surroundings than for
those which probe regions with lower atomic density. Paper published in Phys.
Rev. B 66, 155119 (2002) and available on-line at
http://link.aps.org/abstract/PRB/v66/e155119.Comment: 15 pages, 6 figures. Published in Physical Review B, abstract
available on-line at http://link.aps.org/abstract/PRB/e15511
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